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Journal article

Systemic inflammation alters central 5-HT function as determined by pharmacological MRI.

Abstract:

Considerable evidence indicates a link between systemic inflammation and central 5-HT function. This study used pharmacological magnetic resonance imaging (phMRI) to study the effects of systemic inflammatory events on central 5-HT function. Changes in blood oxygenation level dependent (BOLD) contrast were detected in selected brain regions of anaesthetised rats in response to intravenous administration of the 5-HT-releasing agent, fenfluramine (10 mg/kg). Further groups of rats were pre-trea...

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Publication status:
Published

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Journal:
NeuroImage
Volume:
75
Pages:
177-186
Publication date:
2013-07-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:5a13a708-265a-413c-be79-17faea11c68e
Source identifiers:
387808
Local pid:
pubs:387808

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