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Problems with using mechanisms to solve the problem of extrapolation.

Abstract:

Proponents of evidence-based medicine and some philosophers of science seem to agree that knowledge of mechanisms can help solve the problem of applying results of controlled studies to target populations ('the problem of extrapolation'). We describe the problem of extrapolation, characterize mechanisms, and outline how mechanistic knowledge might be used to solve the problem. Our main thesis is that there are four often overlooked problems with using mechanistic knowledge to solve the proble...

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Publication status:
Published

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Publisher copy:
10.1007/s11017-013-9266-0

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-EBM
Role:
Author
Journal:
Theoretical medicine and bioethics
Volume:
34
Issue:
4
Pages:
275-291
Publication date:
2013-08-05
DOI:
EISSN:
1573-0980
ISSN:
1386-7415
URN:
uuid:5a07cc9e-bc33-48e1-8ed1-2f5710974480
Source identifiers:
415751
Local pid:
pubs:415751

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