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Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle

Abstract:

The aim of this study was to develop a manufacturing protocol for large-scale production of doped titania radiosensitizing nanoparticles (NPs) to establish their activity under hypoxia and to produce a multimodal radiosensitizing embolic particle for cancer treatment. We have previously shown that radiosensitizing NPs can be synthesized from titania doped with rare earth elements, especially gadolinium. To translate this technology to the clinic, a crucial step is to find a suitable, scalable...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.2147/IJN.S127341

Authors


Morrison, RA More by this author
Rybak-Smith, MJ More by this author
Thompson, JM More by this author
Thiebaut, B More by this author
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Funding agency for:
Townley, H
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Grant:
Nanoscale technology enabled healthcare: building the supply chain
Publisher:
Dove Medical Press Publisher's website
Journal:
International Journal of Nanomedicine Journal website
Volume:
12
Pages:
3851—3863
Publication date:
2017-05-18
Acceptance date:
2017-03-07
DOI:
ISSN:
1178-2013
Pubs id:
pubs:695949
URN:
uri:59ff0d85-8212-4464-ac98-4fc4f7eca11a
UUID:
uuid:59ff0d85-8212-4464-ac98-4fc4f7eca11a
Local pid:
pubs:695949

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