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The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding.

Abstract:

The solution structure of the (6)F1(1)F2(2)F2 fragment from the gelatin-binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b). The structure reveals an extensive hydrophobic interface between the non-contiguous (6)F1 and (2)F2 modules. The buried surface area between (6)F1 and (2)F2 ( approximately 870 A(2)) is the largest intermodule interface seen in fibronectin to date. The dissection of (6)F1(1)F2(2)F2 into the (6)F1(1)F2 pair and (2)F2 results in...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/20.7.1519

Authors


Pickford, AR More by this author
Staunton, D More by this author
Campbell, ID More by this author
Journal:
The EMBO journal
Volume:
20
Issue:
7
Pages:
1519-1529
Publication date:
2001-04-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:59f1e8c8-b5a6-43dd-a7ef-245f1e8bf885
Source identifiers:
116661
Local pid:
pubs:116661

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