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Oxygenation during hypothermic rat liver preservation: an in vitro slice study to demonstrate beneficial or toxic oxygenation effects.

Abstract:

Hypothermic machine perfusion (HMP) of abdominal organs is shown to be superior compared to cold storage. However, the question remains if oxygenation is required during preservation as oxygen is essential for energy resynthesis but also generates toxic reactive oxygen species (ROS). To determine if oxygenation should be used during HMP, urea-synthesis rate, adenosine triphosphate (ATP), and generation of ROS were studied in an in vitro model, modeling ischemia-reperfusion injury. Furthermore...

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Publication status:
Published

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Publisher copy:
10.1002/lt.20510

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Journal:
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Volume:
11
Issue:
11
Pages:
1403-1411
Publication date:
2005-11-01
DOI:
EISSN:
1527-6473
ISSN:
1527-6465
Source identifiers:
191022

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