Journal article icon

Journal article

Towards a structure of the HIV-1 envelope glycoprotein gp120: an immunochemical approach.

Abstract:

The HIV-1 surface glycoprotein gp120 binds CD4 in the initial state of virus-cell fusion. The extensive glycosylation of gp120 has thus far precluded definition of its structure by crystallographic methods. As an initial approach to a gp120 structure, the surface topology was mapped using antibodies. First, the regions of gp120 that are accessible on the surface of the native molecule, and those that are internal but exposed after denaturation, are identified. Second, epitopes for antibodies ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1098/rstb.1993.0139

Authors


Jameson, BA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, Jenner Institute
Sodroski, J More by this author
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
342
Issue:
1299
Pages:
83-88
Publication date:
1993-10-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:59dfa985-e6eb-49ca-a479-d2263c428c88
Source identifiers:
14110
Local pid:
pubs:14110

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP