Correction of proliferation and drug sensitivity defects in the progeroid Werner's Syndrome by Holliday junction resolution.

Journal article

The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low proliferative capacity, and drug hypersensitivity are the result of accumulation of alternative DNA structures at stalled or collapsed forks during DNA replication, and Holliday junction ...

Expand abstract

Authors: Rodriguez-Lopez, A; Whitby, M; Borer, C; Bachler, M; Cox, L

• Publication status: Published
• Journal: Rejuvenation research
• Volume: 10
• Issue: 1
• Pages: 27-40
• Publication date: 2007-03-01
• DOI: 10.1089/rej.2006.0503
• EISSN: 1557-8577
• ISSN: 1549-1684
• Language: English
• Keywords: Cells, Cultured; Humans; Werner Syndrome; Fibroblasts; Cell Line; DNA, Cruciform; Holliday Junction Resolvases; Cell Proliferation