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B cell antigen receptor signalling in the balance of tolerance and immunity.

Abstract:
The quantity and quality of signals from the B cell antigen receptor (BCR) drives the positive and negative selection of B lymphocytes and establishes the balance of tolerance and immunity. Experiments using immunoglobulin transgenic mice and mutations in key BCR signalling components have given insight into how the antigen receptor is tuned and how thresholds for qualitatively different outcomes are established and maintained. This research also describes how genetic variants can shift the balance between autoimmunity and tolerance.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Molecular Medicine
Goodnow, CC More by this author
Volume:
215
Pages:
21-30
Publication date:
1998
EISSN:
1935-4657
ISSN:
1528-2511
URN:
uuid:59c98be1-e19e-42d6-b3d3-543e2ac03bc2
Source identifiers:
22656
Local pid:
pubs:22656
ISBN:
0-471-97843-4

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