Journal article icon

Journal article

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.

Abstract:

The surface epithelium lining the intestinal tract renews itself rapidly by a coordinated programme of cell proliferation, migration and differentiation events that is initiated in the crypts of Lieberkühn. It is generally believed that colorectal cancer arises due to mutations that disrupt the normal cellular dynamics of the crypts. Using a spatially structured cell-based model of a colonic crypt, we investigate the likelihood that the progeny of a mutated cell will dominate, or be sloughed ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jtbi.2012.08.002

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
312
Pages:
143-156
Publication date:
2012-11-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:59c8356c-ed5b-489b-8a57-3c143bcfc759
Source identifiers:
349778
Local pid:
pubs:349778

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP