A metathesis-based approach to the synthesis of furans.

Journal article

The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans. [reaction: see text]

Authors: Donohoe, T; Fishlock, L; Lacy, A; Procopiou, P

• Publication status: Published
• Journal: Organic letters
• Volume: 9
• Issue: 6
• Pages: 953-956
• Publication date: 2007-03-01
• DOI: 10.1021/ol062933r
• EISSN: 1523-7052
• ISSN: 1523-7060
• Language: English
• Keywords: Oxidation-Reduction; Furans; Models, Chemical; Acids; Combinatorial Chemistry Techniques; Catalysis