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Journal article

Distinct factors control histone variant H3.3 localization at specific genomic regions.

Abstract:

The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem cells and neuronal precursor cells. Genome-wide patterns of H3.3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci. The H3.3 chaperone Hira is required for H3.3 enrichment at active an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cell.2010.01.003

Authors


Goldberg, AD More by this author
Banaszynski, LA More by this author
Elsaesser, SJ More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
140
Issue:
5
Pages:
678-691
Publication date:
2010-03-04
Acceptance date:
2019-12-31
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:59b76374-af26-4198-94d7-d985ba602151
Source identifiers:
125083
Local pid:
pubs:125083

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