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Journal article

Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease.

Abstract:

Studies on the role that genetic variation may play in a complex human disease can be empowered by an assessment of both disease risk in case-control or family models and of quantitative traits that reflect elements of disease etiology. An excellent example of this can be found for the epsilon4 allele of APOE in relation to Alzheimer's disease (AD) for which association with both risk and age-at-onset (AAO) is evident. Following a recent demonstration that variants of the gene encoding angiot...

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Publication status:
Published

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Publisher copy:
10.1007/s00439-004-1093-y

Authors


Andreasen, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Journal:
Human genetics
Volume:
114
Issue:
5
Pages:
478-483
Publication date:
2004-04-05
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
URN:
uuid:59b41a19-5d58-42f4-84cd-94d319737b30
Source identifiers:
32636
Local pid:
pubs:32636

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