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Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy.

Abstract:

Mouse mutants have a key role in discerning mammalian gene function and modelling human disease; however, at present mutants exist for only 1-2% of all mouse genes. In order to address this phenotype gap, we have embarked on a genome-wide, phenotype-driven, large-scale N-ethyl-N--nitrosourea (ENU) mutagenesis screen for dominant mutations of clinical and pharmacological interest in the mouse. Here we describe the identification of two similar neurological phenotypes and determination of the u...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/9.12.1865

Authors


Isaacs, AM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Hunter, AJ More by this author
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Journal:
Human molecular genetics
Volume:
9
Issue:
12
Pages:
1865-1871
Publication date:
2000-07-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:59b3a070-387c-4966-a818-a3b29cf92a14
Source identifiers:
106407
Local pid:
pubs:106407

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