Journal article

A multicomponent coupling strategy suitable for the synthesis of the triene component of the oxazolomycin antibiotics.

Abstract:: Concise and versatile routes suitable for the synthesis of three geometric isomers of an analogue of the left hand triene sub-unit of oxazolomycin are reported. A strategy based upon a key Heck reaction was unsuccessful, and this was traced to a combination of steric encumbrance and electronic deactivation of the alkene substrate. An alternative Stille coupling strategy, however, proved to be both versatile and high yielding, and is potentially applicable to the synthesis of analogues with va...
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Publication status:: Published

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APA Style

Bulger, P., Moloney, M., & Trippier, P. (2003). A multicomponent coupling strategy suitable for the synthesis of the triene component of the oxazolomycin antibiotics. Organic and Biomolecular Chemistry, 1(21), 3726–3737.

MLA Style

Bulger, P., et al. “A Multicomponent Coupling Strategy Suitable for the Synthesis of the Triene Component of the Oxazolomycin Antibiotics.” Organic and Biomolecular Chemistry, vol. 1, no. 21, 2003, pp. 3726–37.

Chicago Style

Bulger, P, M Moloney, and P Trippier. 2003. “A Multicomponent Coupling Strategy Suitable for the Synthesis of the Triene Component of the Oxazolomycin Antibiotics.” Organic and Biomolecular Chemistry 1 (21): 3726–37.
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Publisher copy:: 10.1039/b306925g

Authors

+ Bulger, P More by this author

Role:

Author

+ Moloney, M More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Organic Chemistry

Role:

Author

+ Trippier, P More by this author

Role:

Author

Bibliographic Details

Journal:: Organic and biomolecular chemistry More from this journal
Volume:: 1
Issue:: 21
Pages:: 3726-3737
Publication date:: 2003-11-01
DOI:: 10.1039/b306925g
EISSN:: 1477-0539
ISSN:: 1477-0520

Item Description

Language:: English
Keywords:: Oxazoles

Magnetic Resonance Spectroscopy

Anti-Bacterial Agents

Gas Chromatography-Mass Spectrometry

Spiro Compounds
Pubs id:: pubs:32558
UUID:: uuid:59adfae6-e058-47b6-b3f5-14ebef80387e
Local pid:: pubs:32558
Source identifiers:: 32558
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2003

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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