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A theoretical framework for quantitative analysis of the molecular basis of costimulation.

Abstract:

We present a theoretical framework for simulating the synaptic accumulation of the costimulatory molecules CD28, CTLA-4, B7-1, and B7-2, based on a system of mean-field, ordinary differential equations, and rigorous biophysical and expression data. The simulations show that binding affinity, stoichiometric properties, expression levels, and, in particular, competition effects all profoundly influence complex formation at cellular interfaces. B7-2 engages 33-fold more CD28 than CTLA-4 at the s...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.175.3.1575

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
3
Pages:
1575-1585
Publication date:
2005-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:599f9159-9059-40cd-ac68-f200f9e93621
Source identifiers:
18240
Local pid:
pubs:18240

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