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Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells

Abstract:

It has been proposed that endogenous H2S mediates oxygen sensing in chemoreceptors; this study investigates the mechanisms by which H 2S excites carotid body type 1 cells. H2S caused a rapid reversible increase in intracellular calcium with EC50≈6 μM. This [Ca2+]i response was abolished in Ca-free Tyrode. In perforated patch current clamp recordings, H2S depolarised type 1 cells from -59 to -35 mV; this was accompanied by a robust increase in [Ca 2+]i. Voltage clamping at the resting membrane...

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Publisher copy:
10.1007/s00424-012-1089-8

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Journal:
Pflugers Archiv European Journal of Physiology
Volume:
463
Issue:
5
Pages:
743-754
Publication date:
2012-05-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:59993c18-039e-43c8-a07f-59d53a8e795f
Source identifiers:
341518
Local pid:
pubs:341518

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