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Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment.

Abstract:

The wide spectrum of clinical outcomes following infection with Mycobacterium tuberculosis is largely determined by the host immune response; therefore, we studied several clinically defined groups of individuals (n = 120) that differ in their ability to contain the bacillus. To quantitate M. tuberculosis-specific T cells directly ex vivo, we enumerated IFN-gamma-secreting CD4 T cells specific for ESAT-6, a secreted Ag that is highly specific for M. tuberculosis, and a target of protective im...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
167
Issue:
9
Pages:
5217-5225
Publication date:
2001-11-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5998c60f-b07f-41fd-b4b1-fafab5ce5cf9
Source identifiers:
13358
Local pid:
pubs:13358

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