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Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T

Abstract:

To a) achieve cardiac 19F-Magnetic Resonance Imaging (MRI) of perfluoro-crown-ether (PFCE) labeled cardiac progenitor stem cells (CPCs) and bone-derived bone marrow macrophages, b) determine label concentration and cellular load limits, and c) achieve spectroscopic and image-based quantification.Theoretical simulations and experimental comparisons of spoiled-gradient echo (SPGR), rapid acquisition with relaxation enhancement (RARE), and steady state at free precession (SSFP) pulse sequences, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0190558

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ORCID:
0000-0001-9225-7572
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
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Funding agency for:
Constantinides, C
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Funding agency for:
Srinivas, M
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Funding agency for:
Schneider, JE
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Funding agency for:
Schneider, JE
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
1
Pages:
1-21
Publication date:
2018-01-11
Acceptance date:
2017-11-27
DOI:
ISSN:
1932-6203
Pubs id:
pubs:819994
URN:
uri:5998a38a-f488-46b8-b90d-d61491e9e051
UUID:
uuid:5998a38a-f488-46b8-b90d-d61491e9e051
Local pid:
pubs:819994
Language:
English

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