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Dichloroacetate for lactic acidosis in severe malaria: a pharmacokinetic and pharmacodynamic assessment.

Abstract:

Lactic acidosis and hypoglycemia are potentially lethal complications of falciparum malaria. We have evaluated the pharmacokinetics and pharmacodynamics of dichloroacetate ([DCA], 46 mg/kg infused over 30 minutes), a stimulant of pyruvate dehydrogenase and a potential treatment for lactic acidosis, in 13 patients with severe malaria and compared the physiological and metabolic responses with those of a control group of patients (n = 32) of equivalent disease severity. The mean +/- SD peak pos...

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Publication status:
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Authors


Krishna, S More by this author
Supanaranond, W More by this author
Pukrittayakamee, S More by this author
Supputamongkol, Y More by this author
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Journal:
Metabolism: clinical and experimental
Volume:
43
Issue:
8
Pages:
974-981
Publication date:
1994-08-05
DOI:
EISSN:
1532-8600
ISSN:
0026-0495
URN:
uuid:5997a45b-40b5-4a99-a236-f51e35755c9a
Source identifiers:
44600
Local pid:
pubs:44600

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