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Single-molecule analysis of bacterial DNA repair and mutagenesis

Abstract:

Ubiquitous conserved processes that repair DNA damage are essential for the maintenance and propagation of genomes over generations. Then again, inaccuracies in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes. Building on decades of research using genetics and biochemistry, unprecedented quantitative insight into DNA repair mechanisms has come from the new-found ability to measure single proteins in vitro and inside individual living cells. This has br...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-3579-0888
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-2104-5430
Publisher:
Annual Reviews Publisher's website
Journal:
Annual Review of Biophysics Journal website
Volume:
46
Pages:
411-432
Publication date:
2017-05-22
Acceptance date:
2017-02-06
DOI:
EISSN:
1936-1238
ISSN:
1936-122X
Pubs id:
pubs:688842
URN:
uri:5992d154-6704-41d8-be99-c7de6454b5ba
UUID:
uuid:5992d154-6704-41d8-be99-c7de6454b5ba
Local pid:
pubs:688842

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