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Journal article

Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses.

Abstract:

Background

Vaccination generating a robust memory population of CD8+ T cells may provide protection against cancer. However, immune therapies for cancer are influenced by the local tumour immune microenvironment. An infiltrate of T cells into tumours of people with colorectal cancer has proven to be a significant indicator of good prognosis.

Methods

We used an intracaecal mouse model of cancer to determine whether a protective immune response against a mucosal gut...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12865-016-0178-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
ORCID:
0000-0003-3967-016X
Girardin, A More by this author
Genesis Oncology Trust More from this funder
Lottery Health New Zealand More from this funder
University of Otago More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Immunology Journal website
Volume:
17
Issue:
1
Pages:
39
Publication date:
2016-10-05
Acceptance date:
2016-10-13
DOI:
EISSN:
1471-2172
Pubs id:
pubs:656785
URN:
uri:597dd026-105f-4a7b-9fee-36319f6bfc33
UUID:
uuid:597dd026-105f-4a7b-9fee-36319f6bfc33
Local pid:
pubs:656785

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