Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology.

Journal article

The myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal disorders of the haematopoietic stem cell and primarily involve cells of the myeloid lineage. Using cDNA microarrays comprising 6000 human genes, we studied the gene expression profiles in the neutrophils of 21 MDS patients, seven of which had the 5q- syndrome, and two acute myeloid leukaemia (AML) patients when compared with the neutrophils from pooled healthy controls. Data analysis showed a high level of heterogen...

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Authors: Pellagatti, A; Esoof, N; Watkins, F; Langford, C; Vetrie, D

• Publication status: Published
• Journal: British journal of haematology
• Volume: 125
• Issue: 5
• Pages: 576-583
• Publication date: 2004-06-01
• DOI: 10.1111/j.1365-2141.2004.04958.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Up-Regulation; Oligonucleotide Array Sequence Analysis; Down-Regulation; Humans; Myelodysplastic Syndromes; Neutrophils; Gene Expression Profiling; Reverse Transcriptase Polymerase Chain Reaction; Multigene Family