Journal article icon

Journal article

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.

Abstract:

OBJECTIVE: Proteomic analysis has previously shown that activin A, a member of the transforming growth factor beta family, is produced by human articular cartilage. This study was undertaken to investigate whether activin A affects cartilage matrix catabolism and how its production is regulated. METHODS: The effect of exogenous activin A on interleukin-1-induced aggrecanase-generated neoepitope production was assessed by Western blotting, using medium from human cartilage explants. Levels of...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/art.22953

Authors


Alexander, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Hermansson, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Arthritis and rheumatism
Volume:
56
Issue:
11
Pages:
3715-3725
Publication date:
2007-11-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:59742677-e62c-43e1-8f7f-e9894fd42dec
Source identifiers:
226710
Local pid:
pubs:226710

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP