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A study of viral and cellular factors in the regulation of the influenza virus RNA-dependent RNA polymerase

Abstract:

The segmented negative-sense vRNA genome of influenza A virus is replicated via a complementary RNA (cRNA) intermediate by the viral RNA-dependent RNA polymerase (RdRP). The replicative intermediate has been thought to exist as a complementary ribonucleoprotein (cRNP) complex. Development of an RNA-based affinity-purification strategy for the isolation of viral ribonucleoprotein complexes enabled the structural and functional characterisation of the previously uncharacterised cRNP complex....

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Institution:
University of Oxford
Oxford college:
Brasenose College
Department:
Medical Sciences Division - Pathology

Contributors

Role:
Supervisor
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Funding agency for:
Ashley D York
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:5958fafd-4c91-4434-910e-29e2dd0539b9
Local pid:
ora:9174

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