Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa.

Journal article

Understanding adaptation by natural selection requires understanding the genetic factors that determine which beneficial mutations are available for selection. Here, using experimental evolution of rifampicin-resistant Pseudomonas aeruginosa, we show that different genotypes vary in their capacity for adaptation to the cost of antibiotic resistance. We then use sequence data to show that the beneficial mutations associated with fitness recovery were specific to particular genetic backgrounds,...

Expand abstract

Authors: Hall, A; Griffiths, V; Maclean, C; Colegrave, N

• Publication status: Published
• Journal: Proceedings. Biological sciences / The Royal Society
• Volume: 277
• Issue: 1681
• Pages: 643-650
• Publication date: 2010-02-01
• DOI: 10.1098/rspb.2009.1630
• EISSN: 1471-2954
• ISSN: 0962-8452
• Language: English
• Keywords: Adaptation, Biological; Directed Molecular Evolution; Pseudomonas aeruginosa; Base Sequence; Rifampin; Molecular Sequence Data; Mutation; DNA Primers; Bacterial Proteins; Drug Resistance, Microbial; Genotype; Sequence Analysis, DNA; Selection, Genetic