The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

Journal article

Helper cell induction to nonparticle antigens in vitro requires the cooperation of T cells and macrophages, but does not occur if the macrophages are allogenic. The reasons for this were investigated. Malfunction of allogenic macrophages was excluded by cultures with their syngenic T cells; suppressor cell induction was excluded by admixture experiments. Thus, T cells and macrophages only cooperated if they were genetically similar. The genetic locus (loci) involved was mapped. Using con...

Expand abstract

Authors: Erb, P; Feldmann, M

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 142
• Issue: 2
• Pages: 460-472
• Publication date: 1975-08-01
• DOI: 10.1084/jem.142.2.460
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Histocompatibility Antigens; Mice, Inbred Strains; Carrier Proteins; Hemocyanin; Antigens; Mice; Animals; Polymers; Spleen; Lymph Nodes; Amino Acids; Cells, Cultured; Chromosome Mapping; Macrophages; Antibody-Producing Cells; T-Lymphocytes