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The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

Abstract:

Helper cell induction to nonparticle antigens in vitro requires the cooperation of T cells and macrophages, but does not occur if the macrophages are allogenic. The reasons for this were investigated. Malfunction of allogenic macrophages was excluded by cultures with their syngenic T cells; suppressor cell induction was excluded by admixture experiments. Thus, T cells and macrophages only cooperated if they were genetically similar. The genetic locus (loci) involved was mapped. Using con...

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Publication status:
Published

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Publisher copy:
10.1084/jem.142.2.460

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
142
Issue:
2
Pages:
460-472
Publication date:
1975-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:5944545c-b2b3-4e3f-a292-ba4f8b8ff0fb
Source identifiers:
481896
Local pid:
pubs:481896

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