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TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

Abstract:

The transcription factor NF-kappaB is a pivotal intracellular regulator of many inflammatory responses and it has been proposed that it represents a potential therapeutic target. As chemokines are important for the progress of an inflammatory response by the recruitment of immuno-competent cells, the role NF-kappaB plays in TNFalpha- or lipopolysaccharides (LPS)-induced chemokine secretion by human monocyte-derived macrophages was examined. Secretion of the CXC chemokines IL-8, GROalpha and E...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
32
Issue:
7
Pages:
2037-2045
Publication date:
2002-07-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:5940c69e-30da-4921-a0c1-b03c1f9d987c
Source identifiers:
224772
Local pid:
pubs:224772

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