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Journal article

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils

Abstract:

Background: Eosinophilic airway inflammation is observed in 10-30% of COPD subjects. Whether increased eosinophils or impairment in their clearance by macrophages is associated with the severity and frequency of exacerbations is unknown.

Methods: We categorised 103 COPD subjects into 4 groups determined by the upper limit of normal for their cytoplasmic macrophage red hue (<6%), an indirect measure of macrophage efferocytosis of eosi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2466-14-112

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Pulmonary Medicine Journal website
Volume:
14
Article number:
112
Publication date:
2014-07-09
Acceptance date:
2014-07-01
DOI:
EISSN:
1471-2466
Source identifiers:
476274
Language:
English
Keywords:
UUID:
uuid:593f5f40-136c-4f8b-b74a-481cc7506668
Local pid:
pubs:476274
Deposit date:
2014-07-21

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