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Systems genetics of nonsyndromic orofacial clefting provides insights into its complex aetiology

Abstract:

Nonsyndromic oral clefting (NSOC) is although one of the most common congenital disorders worldwide, its underlying molecular basis remains elusive. This process has been hindered by the overwhelmingly high level of heterogeneity observed. Given that hitherto multiple loci and genes have been associated with NSOC, and that complex diseases are usually polygenic and show a considerable level of missing heritability, we used a systems genetics approach to reconstruct the NSOC network by integra...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41431-018-0263-7

Authors


Razaghi-Moghadam, Z More by this author
Namipashaki, A More by this author
Farahmand, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
BDI-NDM
ORCID:
0000-0003-0908-0484
Publisher:
Nature Publishing Group Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
27
Pages:
226–234
Publication date:
2018-09-25
Acceptance date:
2018-08-09
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Pubs id:
pubs:922592
URN:
uri:5936d2d1-be63-4aac-97e0-a47d517fb80d
UUID:
uuid:5936d2d1-be63-4aac-97e0-a47d517fb80d
Local pid:
pubs:922592
Language:
English

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