Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts.

Journal article

BACKGROUND: The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain. Leukocyte-associated immunoglobulin-like receptor-1 also ligates collagen but generates inhibitory signals through immunoreceptor tyrosine-based inhibitory motifs. Thus far, the cellular expression of glycoprotein VI and leukocyte-associated immunoglobulin-like receptor-1 appears mutually exclusive. DESIGN AND ME...

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Authors: Steevels, T; Westerlaken, G; Tijssen, MR; Coffer, P; Lenting, P

• Journal: Haematologica
• Volume: 95
• Issue: 12
• Pages: 2005-2012
• Publication date: 2010-12-01
• DOI: 10.3324/haematol.2010.026120
• EISSN: 1592-8721
• ISSN: 0390-6078
• Language: English
• Keywords: Receptors, Collagen; Receptors, Immunologic; Antigens, CD34; Megakaryocytes; Humans; Integrin alpha2beta1; Cells, Cultured; Megakaryocyte Progenitor Cells; Flow Cytometry; Fetal Blood; Thrombopoiesis; Bone Marrow Cells; Cell Line, Tumor; Blood Platelets; Hematopoietic Stem Cells; Platelet Membrane Glycoproteins; Multipotent Stem Cells