Chromosomal translocation engineering to recapitulate primary events of human cancer.

Journal article

Mouse models of human cancers are important for understanding determinants of overt disease and for "preclinical" development of rational therapeutic strategies; for instance, based on macrodrugs. Chromosomal translocations underlie many human leukemias, sarcomas, and epithelial tumors. We have developed three technologies based on homologous recombination in mouse ES cells to mimic human chromosome translocations. The first, called the knockin method, allows creation of fusion genes like tho...

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Authors: Forster, A; Pannell, R; Drynan, L; Cano, F; Chan, N

• Journal: Cold Spring Harbor symposia on quantitative biology
• Volume: 70
• Issue: 0
• Pages: 275-282
• Publication date: 2005-01-01
• DOI: 10.1101/sqb.2005.70.008
• EISSN: 1943-4456
• ISSN: 0091-7451
• Language: English
• Keywords: Chromosomes, Human; Genetic Engineering; Recombination, Genetic; Mice, Mutant Strains; Disease Models, Animal; Animals; Translocation, Genetic; Neoplasms; Mice; Humans; Inversion, Chromosome; Models, Genetic