Journal article icon

Journal article

Chromosomal translocation engineering to recapitulate primary events of human cancer.

Abstract:

Mouse models of human cancers are important for understanding determinants of overt disease and for "preclinical" development of rational therapeutic strategies; for instance, based on macrodrugs. Chromosomal translocations underlie many human leukemias, sarcomas, and epithelial tumors. We have developed three technologies based on homologous recombination in mouse ES cells to mimic human chromosome translocations. The first, called the knockin method, allows creation of fusion genes like tho...

Expand abstract

Actions


Access Document


Publisher copy:
10.1101/sqb.2005.70.008

Authors


Forster, A More by this author
Pannell, R More by this author
Expand authors...
Journal:
Cold Spring Harbor symposia on quantitative biology
Volume:
70
Issue:
0
Pages:
275-282
Publication date:
2005
DOI:
EISSN:
1943-4456
ISSN:
0091-7451
URN:
uuid:592e8236-0574-4fd2-9424-e7b282143dcc
Source identifiers:
324255
Local pid:
pubs:324255

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP