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Ending the message: poly(A) signals then and now.

Abstract:

Polyadenylation [poly(A)] signals (PAS) are a defining feature of eukaryotic protein-coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and subsequently shown to require flanking, auxiliary elements for both 3'-end cleavage and polyadenylation of premessenger RNA (pre-mRNA) as well as to promote downstream transcriptional termination. More recent genomic analysis has established the generality of the PAS for eukaryotic mRNA. Evidence for the mechanism of mRNA 3'-e...

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Publication status:
Published

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Publisher copy:
10.1101/gad.17268411

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Genes and development
Volume:
25
Issue:
17
Pages:
1770-1782
Publication date:
2011-09-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:592a08db-dcd8-4120-9cb3-57a8ad5494a0
Source identifiers:
175181
Local pid:
pubs:175181

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