Erythrocytes alter the pattern of renal hypoxic injury: predominance of proximal tubular injury with moderate hypoxia.

Journal article

1. The distribution of morphological injury was assessed qualitatively and quantitatively in the perfused rat kidney in vitro at controlled rates of oxygen delivery in the presence of low concentrations of erythrocytes. 2. In control kidneys (total oxygen delivery approximately 32 mumol/min per kidney) no injury was seen in the medullary thick ascending limb of Henle's loop (MTAL) whilst 11 +/- 5(SD)% of proximal tubules sustained damage. 3. Mild hypoxia (total oxygen delivery approximately 2...

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Authors: Endre, Z; Ratcliffe, P; Tange, J; Ferguson, D; Radda, G

• Publication status: Published
• Journal: Clinical science (London, England : 1979)
• Volume: 76
• Issue: 1
• Pages: 19-29
• Publication date: 1989-01-01
• EISSN: 1470-8736
• ISSN: 0143-5221
• Language: English
• Keywords: Animals; Acute Kidney Injury; Rats; Kidney Cortex; Kidney Tubules, Proximal; Cytoplasm; Hemoglobins; Rats, Inbred Strains; Erythrocytes; Microscopy, Electron; Microvilli; Male; Oxygen Consumption