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Linkage of extracellular and intracellular control of cytosolic Ca2+ in rat osteoclasts in the presence of thapsigargin.

Abstract:

Cytosolic [Ca2+] was measured in single osteoclasts using fura-2 in experiments investigating the effects of Ca2+ "receptor" activation using thapsigargin as a means of depleting intracellular Ca2+ stores. Application of 4 microM thapsigargin to osteoclasts in Ca(2+)-free solutions resulted in an elevation of cytosolic [Ca2+]. Under similar conditions, activation of the osteoclast Ca2+ receptor by the substitute divalent cation agonist, Ni2+, resulted in a transient elevation of cytosolic [Ca...

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Publisher copy:
10.1002/jbmr.5650080809

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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
8
Issue:
8
Pages:
961-967
Publication date:
1993-08-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:5920ba2d-14ae-4b14-ada9-81971004ffcf
Source identifiers:
475720
Local pid:
pubs:475720

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