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Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions

Abstract:

It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 ...

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Publisher copy:
10.1093/carcin/bgl159

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Journal:
Carcinogenesis
Volume:
28
Issue:
2
Pages:
414-422
Publication date:
2007-02-05
DOI:
EISSN:
1460-2180
ISSN:
0143-3334
URN:
uuid:59205844-04c6-4d14-8091-8b39059702a5
Source identifiers:
74908
Local pid:
pubs:74908
Language:
English

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