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Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport.

Abstract:

The B cell line 721.174 has lost the ability to present intracellular antigens to major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTL). This phenotype results from a homozygous deletion in the MHC that includes the peptide transporter genes TAP1 and TAP2, and the proteasome subunits LMP2 and LMP7. Recent work has shown that such cells transfected with TAP genes load their class I molecules with endogenous peptides, and present several viral epitopes to class...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830250238

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Elliott, T More by this author
Trowsdale, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
European journal of immunology
Volume:
25
Issue:
2
Pages:
554-562
Publication date:
1995-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:591e2d03-3720-4d44-8b45-0283fafe3214
Source identifiers:
35723
Local pid:
pubs:35723

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