- Abstract:
-
T cell activation requires both antigen specific and co-stimulatory signals that include the interaction of CD28 with its ligands CD80 and CD86. These signals are delivered by antigen presenting cells (APC) in the context of the immunological synapse (IS). Reorganization of the cytoskeleton is required for the formation and maintenance of the IS. Our results show that a highly conserved polylysine motif in CD86 cytoplasmic tail, herein referred to as the K4 motif, is responsible for the const...
Expand abstract - Publisher copy:
- 10.1016/j.bbrc.2012.05.116
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 423
- Issue:
- 2
- Pages:
- 301-307
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:591a1058-303e-41ff-b5e0-2bd3167d1769
- Source identifiers:
-
334702
- Local pid:
- pubs:334702
- Copyright date:
- 2012
Journal article
A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.
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