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A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

Abstract:

T cell activation requires both antigen specific and co-stimulatory signals that include the interaction of CD28 with its ligands CD80 and CD86. These signals are delivered by antigen presenting cells (APC) in the context of the immunological synapse (IS). Reorganization of the cytoskeleton is required for the formation and maintenance of the IS. Our results show that a highly conserved polylysine motif in CD86 cytoplasmic tail, herein referred to as the K4 motif, is responsible for the const...

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Publisher copy:
10.1016/j.bbrc.2012.05.116

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Biochemical and biophysical research communications
Volume:
423
Issue:
2
Pages:
301-307
Publication date:
2012-06-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:591a1058-303e-41ff-b5e0-2bd3167d1769
Source identifiers:
334702
Local pid:
pubs:334702

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