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Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

Abstract:

Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection,...

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Publication status:
Published

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Publisher copy:
10.1038/ni853

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nature immunology
Volume:
3
Issue:
12
Pages:
1208-1213
Publication date:
2002-12-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:590c69df-bf95-4260-9efe-7066a3572a03
Source identifiers:
8699
Local pid:
pubs:8699

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