Journal article
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
- Abstract:
-
Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection,...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ni853
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Bibliographic Details
- Journal:
- Nature immunology
- Volume:
- 3
- Issue:
- 12
- Pages:
- 1208-1213
- Publication date:
- 2002-12-01
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Source identifiers:
-
8699
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:8699
- UUID:
-
uuid:590c69df-bf95-4260-9efe-7066a3572a03
- Local pid:
- pubs:8699
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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