Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

Lin, CY; Graca, L; Cobbold, SP; Waldmann, H

Abstract:

Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection,...

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APA Style

Lin, C. Y., Graca, L., Cobbold, S. P., & Waldmann, H. (2002). Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nature Immunology, 3(12), 1208–1213.

MLA Style

Lin, C. Y., et al. “Dominant Transplantation Tolerance Impairs CD8+ T Cell Function but Not Expansion.” Nature Immunology, vol. 3, no. 12, 2002, pp. 1208–13.

Chicago Style

Lin, CY, L Graca, SP Cobbold, and H Waldmann. 2002. “Dominant Transplantation Tolerance Impairs CD8+ T Cell Function but Not Expansion.” Nature Immunology 3 (12): 1208–13.
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