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Journal article

Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts.

Abstract:

Older age has been linked to increased transplant-related mortality from graft-versus-host disease (GvHD). Depletion of T cells from stem cell grafts seems to protect from complications of GvHD particularly in older patients. After myeloablative conditioning, patients with haematological malignancies received allogeneic grafts from HLA identical siblings. For GvHD prophylaxis, PBPC grafts were treated ex vivo with anti-CD52, and therapeutic doses of cyclosporin until day +90. Survival of pati...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bmt.1705119

Authors


Novitzky, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Bone marrow transplantation
Volume:
36
Issue:
8
Pages:
675-682
Publication date:
2005-10-05
DOI:
EISSN:
1476-5365
ISSN:
0268-3369
URN:
uuid:59051e96-db5f-4f08-824e-a02b4699ea67
Source identifiers:
9911
Local pid:
pubs:9911

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