Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial.

Journal article

BACKGROUND: In the non-curative setting, the sequence in which anticancer agents are used, singly or in combination, may be important if patients are to receive the maximum period of disease control with the minimum of adverse effects. We compared sequential and combination chemotherapy strategies in patients with unpretreated advanced or metastatic colorectal cancer, who were regarded as not potentially curable irrespective of response. METHODS: We studied patients with advanced colorectal c...

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Authors: Seymour, M; Maughan, T; Ledermann, J; Topham, C; James, R

• Publication status: Published
• Journal: Lancet
• Volume: 370
• Issue: 9582
• Pages: 143-152
• Publication date: 2007-07-01
• DOI: 10.1016/s0140-6736(07)61087-3
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Drug Administration Schedule; Humans; Survival Analysis; Colorectal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Female; Male; Leucovorin; National Cancer Research Institute Colorectal Clinical Studies Group; Prognosis; Organoplatinum Compounds; Middle Aged; FOCUS Trial Investigators; Fluorouracil; Aged; Camptothecin