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Journal article

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

Abstract:

UNLABELLED: Inhibition of malonyl-coenzyme A decarboxylase (MCD) shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ~40% of patients with MCD deficiency are diagnosed with cardiomyopathy during infancy. AIM: To clarify the link between MCD deficiency and cardiac dysfunction in early life and to determine the contributing systemic and cardiac metabolic perturbations. METHODS AND RESULTS: MCD knockout...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2014.07.008

Authors


Aksentijević, D More by this author
McAndrew, DJ More by this author
Karlstädt, A More by this author
Sebag-Montefiore, L More by this author
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Publisher:
Academic Press
Journal:
Journal of molecular and cellular cardiology
Volume:
75
Pages:
76-87
Publication date:
2014-10-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:58f02450-dd79-42d0-a52e-805df3b789d2
Source identifiers:
477924
Local pid:
pubs:477924

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