T cell-dependent mediator in the immune response. III. The role of non-specific factor (NSF) in the in vitro immune response.

Journal article

Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.

Authors: Waldmann, H

• Publication status: Published
• Journal: Immunology
• Volume: 28
• Issue: 3
• Pages: 497-507
• Publication date: 1975-03-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Antigens; Antibody Specificity; Antigen-Antibody Reactions; Erythrocytes; Mice, Inbred CBA; Immunity; Freund's Adjuvant; Mice; Antibody Formation; Hemolytic Plaque Technique; Animals; Carrier Proteins; Immunization; Cells, Cultured; Protein Binding; Sheep; T-Lymphocytes; Haptens; Antibody-Producing Cells; Antibodies