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The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat.

Abstract:

The effect of local application of morphine (5 microgram) into the ventral tegmental area (VTA) or substantia nigra, pars compacta (SNc) on spontaneous activity was studied in the rat. Morphine in the VTA but not SNc produced an enhancement of locomotor activity which became progressively augmented with repeated injections. This effect could be blocked by systemic injections of naloxone or haloperidol. It is suggested that stimulation of opiate receptors in the vicinity of dopamine cell bodie...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Neuroscience letters
Volume:
14
Issue:
2-3
Pages:
207-212
Publication date:
1979-10-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:58e7934f-e450-4da1-b26b-104328b0713f
Source identifiers:
613
Local pid:
pubs:613

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