Journal article
The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity.
- Abstract:
-
Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of L-arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, along with improved histological and behavioral measures in experimental models of embolic stroke. However, in animal models of mechanically induced ischemia, alteplase can exacerbate ischemic damage...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/jcbfm.2010.149
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Bibliographic Details
- Journal:
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Volume:
- 30
- Issue:
- 11
- Pages:
- 1804-1816
- Publication date:
- 2010-11-01
- DOI:
- EISSN:
-
1559-7016
- ISSN:
-
0271-678X
- Source identifiers:
-
67495
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:67495
- UUID:
-
uuid:58e72c1f-4393-418b-8647-4d72b68b0563
- Local pid:
- pubs:67495
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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