Journal article icon

Journal article

The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity.

Abstract:

Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of L-arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, along with improved histological and behavioral measures in experimental models of embolic stroke. However, in animal models of mechanically induced ischemia, alteplase can exacerbate ischemic damage...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/jcbfm.2010.149

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
30
Issue:
11
Pages:
1804-1816
Publication date:
2010-11-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:58e72c1f-4393-418b-8647-4d72b68b0563
Source identifiers:
67495
Local pid:
pubs:67495

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP