- Abstract:
-
Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of L-arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, along with improved histological and behavioral measures in experimental models of embolic stroke. However, in animal models of mechanically induced ischemia, alteplase can exacerbate ischemic damage...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/jcbfm.2010.149
-
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- Journal:
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Volume:
- 30
- Issue:
- 11
- Pages:
- 1804-1816
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1559-7016
- ISSN:
-
0271-678X
- URN:
-
uuid:58e72c1f-4393-418b-8647-4d72b68b0563
- Source identifiers:
-
67495
- Local pid:
- pubs:67495
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity.
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