Journal article icon

Journal article

Germline mutations in PALB2, BRCA1, and RAD51C, which regulate DNA recombination repair, in patients with gastric cancer

Abstract:

Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutatio...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1053/j.gastro.2016.12.010

Authors


Expand authors...
No Stomach For Cancer Inc More from this funder
University of California, Davis More from this funder
More from this funder
Grant:
Intramural Research Program of the National Cancer Institute, the Division of Cancer Epidemiology and Genetics
Publisher:
AGA Institute Publisher's website
Journal:
Gastroenterology Journal website
Volume:
152
Issue:
5
Pages:
983–986.e6
Publication date:
2016-12-23
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Pubs id:
pubs:667540
URN:
uri:58e2f899-ede8-4c49-be0d-e95b574fb37a
UUID:
uuid:58e2f899-ede8-4c49-be0d-e95b574fb37a
Local pid:
pubs:667540
Paper number:
5
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP