Journal article icon

Journal article

The biosynthetic origin of diketopiperazines derived from D-proline

Abstract:
Investigations reveal that the structures assigned to D-α-amino acid containing diketopiperazines (DKPs) 21-25 isolated from the sponge Calyx CF. podatypa have been reported incorrectly. Synthetic studies and comparison with literature data have enabled the structures of these DKPs to be correctly reassigned. Evidence is presented to suggest that naturally occurring D-Pro-L-Xxx-DKPs are artifacts resulting from non-enzymatic epimerisation of the corresponding L-Pro-L-Xxx-DKP natural products.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1039/a802702a

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Parkin, RM More by this author
Sanchez-Sancho, F More by this author
Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Issue:
15
Pages:
2313-2320
Publication date:
1998-08-07
DOI:
EISSN:
1364-5463
ISSN:
0300-922X
URN:
uuid:58d581c2-219d-4921-9dd7-9ec902227a32
Source identifiers:
110627
Local pid:
pubs:110627
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP