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Critical roles of CTP synthase N-terminal in cytoophidium assembly

Abstract:

Several metabolic enzymes assemble into distinct intracellular structures in prokaryotes and eukaryotes suggesting an important functional role in cell physiology. The CTP-generating enzyme CTP synthase forms long filamentous structures termed cytoophidia in bacteria, yeast, fruit flies and human cells independent of its catalytic activity. However, the amino acid determinants for protein-protein interaction necessary for polymerisation remained unknown. In this study, we systematically analy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.yexcr.2017.03.042

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Publisher:
Elsevier Publisher's website
Journal:
Experimental Cell Research Journal website
Volume:
354
Issue:
2
Pages:
122-133
Publication date:
2017-03-22
Acceptance date:
2017-03-20
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
Pubs id:
pubs:687164
URN:
uri:58d4d17c-0cb7-4b9d-a0d2-ce0db7b0a63e
UUID:
uuid:58d4d17c-0cb7-4b9d-a0d2-ce0db7b0a63e
Local pid:
pubs:687164

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