Risk alleles for multiple sclerosis in multiplex families.

Journal article

OBJECTIVE: We assessed the hypotheses that non-major histocompatibility complex multiple sclerosis (MS) susceptibility loci would be common to sporadic cases and multiplex families, that they would have larger effects in multiplex families, and that the aggregation of susceptibility loci contributes to the increased prevalence of MS in such families. METHODS: A set of 43 multiplex families comprising 732 individuals and 211 affected subjects was genotyped for 13 MS candidate genes identified...

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Authors: D'Netto, M; Ward, H; Morrison, K; Ramagopalan, S; Dyment, D

• Publication status: Published
• Journal: Neurology
• Volume: 72
• Issue: 23
• Pages: 1984-1988
• Publication date: 2009-06-01
• DOI: 10.1212/wnl.0b013e3181a92c25
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Histocompatibility Antigens; Pedigree; Genetic Variation; Humans; Receptors, Interleukin-7; Genetic Testing; Chromosome Mapping; DNA Mutational Analysis; Prevalence; Risk Factors; Female; Genetic Predisposition to Disease; Genotype; Family; Multiple Sclerosis; Gene Frequency; Lectins, C-Type; Linkage Disequilibrium; Nuclear Proteins; Monosaccharide Transport Proteins; Case-Control Studies; Alleles; Genome-Wide Association Study; Male; Polymorphism, Single Nucleotide; Molecular Epidemiology; Interleukin-2 Receptor alpha Subunit; Antigens, CD58