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Journal article

Polymorphisms in the F pocket of HLA–B27 subtypes strongly affect assembly, chaperone interactions, and heavy‐chain misfolding

Abstract:
Objective HLA–B27 is associated with the inflammatory spondyloarthritides (SpA), although subtypes HLA–B*27:06 and HLA–B*27:09 are not. These subtypes differ from the HLA–B*27:05 disease‐associated allele primarily at residues 114 and 116 of the heavy chain, part of the F pocket of the antigen‐binding groove. Dimerization of HLA–B27 during assembly has been implicated in disease onset. The purpose of this study was to investigate the factors that influence differences in dime... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/art.39948

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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
69
Issue:
3
Pages:
610-621
Publication date:
2017-02-27
Acceptance date:
2016-09-29
DOI:
ISSN:
2326-5205
Pubs id:
pubs:853809
URN:
uri:58bbd366-e4e4-41d5-b890-e52859ed11a1
UUID:
uuid:58bbd366-e4e4-41d5-b890-e52859ed11a1
Local pid:
pubs:853809

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