- Abstract:
-
Objective HLA–B27 is associated with the inflammatory spondyloarthritides (SpA), although subtypes HLA–B*27:06 and HLA–B*27:09 are not. These subtypes differ from the HLA–B*27:05 disease‐associated allele primarily at residues 114 and 116 of the heavy chain, part of the F pocket of the antigen‐binding groove. Dimerization of HLA–B27 during assembly has been implicated in disease onset. The purpose of this study was to investigate the factors that influence differences in dime... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 186.6KB)
-
- Publisher copy:
- 10.1002/art.39948
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- Arthritis and Rheumatology Journal website
- Volume:
- 69
- Issue:
- 3
- Pages:
- 610-621
- Publication date:
- 2017-02-27
- Acceptance date:
- 2016-09-29
- DOI:
- ISSN:
-
2326-5205
- Pubs id:
-
pubs:853809
- URN:
-
uri:58bbd366-e4e4-41d5-b890-e52859ed11a1
- UUID:
-
uuid:58bbd366-e4e4-41d5-b890-e52859ed11a1
- Local pid:
- pubs:853809
- Copyright holder:
- American College of Rheumatology
- Copyright date:
- 2017
- Notes:
-
Copyright © 2016, American College of Rheumatology. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/art.39948
Journal article
Polymorphisms in the F pocket of HLA–B27 subtypes strongly affect assembly, chaperone interactions, and heavy‐chain misfolding
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