Parent-of-origin effects in MS: observations from avuncular pairs.

Journal article

BACKGROUND: Multiple sclerosis (MS) is a complex neurologic disease of unknown etiology and inheritance pattern, but with increasing incidence among females. The study of aunt/uncle-niece/nephew (AUNN) pairs has potential to shed light on the on complex trait inheritance as this group can be divided into eight different pair types by gender, MS status, and parent of origin. METHODS: Using a cohort of 807 avuncular MS families with 938 affected AUNN pairs ascertained from a longitudinal, popu...

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Authors: Herrera, B; Ramagopalan, S; Lincoln, MR; Orton, S; Chao, M

• Publication status: Published
• Journal: Neurology
• Volume: 71
• Issue: 11
• Pages: 799-803
• Publication date: 2008-09-01
• DOI: 10.1212/01.wnl.0000312377.50395.00
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Parents; Heredity; Multiple Sclerosis; Cohort Studies; Pedigree; Inheritance Patterns; Humans; Female; Male; Longitudinal Studies